[Influenza virus infections in infants aged less than two years old].
Identifieur interne : 000612 ( Main/Exploration ); précédent : 000611; suivant : 000613[Influenza virus infections in infants aged less than two years old].
Auteurs : C. Calvo Rey [Espagne] ; M L García García ; I. Casas Flecha ; F. Martín Del Valle ; M. Centeno Jiménez ; P. Pérez-Bre ASource :
- Anales de pediatria (Barcelona, Spain : 2003) [ 1695-4033 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- physiopathologie : Grippe humaine.
- statistiques et données numériques : Hospitalisation.
- épidémiologie : Espagne, Grippe humaine, Infections de l'appareil respiratoire.
- Femelle, Humains, Mâle, Nourrisson.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Spain.
- epidemiology : Influenza, Human, Respiratory Tract Infections.
- physiopathology : Influenza, Human.
- statistics & numerical data : Hospitalization.
- Female, Humans, Infant, Male.
Abstract
INTRODUCTION
Influenza is a major cause of respiratory tract illness in infants. The clinical characteristics of these infections are non-specific and the burden of influenza is frequently underestimated in very young children. The objective of this study was to describe confirmed influenza infections in infants < 2 years attended in a level II public hospital. A second-rate aim was to compare influenza infections in hospitalized infants with respiratory syncytial virus (VRS) infection in the same population.
PATIENTS AND METHODS
We performed a descriptive, prospective study between 1991 and 2003 in infants younger than 24 months of age, who were admitted to the Severo Ochoa Hospital (Leganés. Madrid) with fever or respiratory tract infection. Virological diagnosis was made with direct immunofluorescent assay and/or reverse transcription-polymerase chain reaction on specimens obtained from nasopharyngeal washings. The patients' clinical characteristics were recorded. Patients with influenza infection were compared with a similar group of infants with RSV infection.
RESULTS
We analyzed hospitalized 100 infants with influenza infection. Influenza caused 4.1% of the admissions in infants with fever or respiratory tract infection. Influenza A was isolated in 83%, influenza B in 12% and influenza C in 5% of the patients. The mean age of hospitalized infants was 8.3 +/- 5.9 months and the most frequent clinical diagnoses were bronchiolitis in 38%, recurrent wheezing in 25%, upper respiratory tract infection in 19% and pneumonia in 9%. Fever > 38 degrees C was present in 83% of the patients. Radiologic infiltrate was found in 65% of the children. Oxygen saturation less then 95% was present in 44%. In children under 6 months of age fever was less frequent (p = 0.049) and upper respiratory tract infection was more frequent (p = 0.01). Patients with influenza virus infection were older (p = 0.002), more frequently presented fever (p < 0.0001) and radiologic infiltrate (p < 0.001) than infants with RSV infection. Bronchiolitis was more frequent in the RSV group (p = 0.006).
CONCLUSIONS
Influenza infection is a major cause of respiratory tract disease in hospitalized infants. It is an etiologic cause of bronchiolitis, recurrent wheezing, and fever and radiologic consolidations are frequent. Clinical presentation is milder in children under 6 month of age. The characteristics of influenza infection differ substantially from those of RSV infection.
DOI: 10.1157/13076763
PubMed: 15989867
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Influenza virus infections in infants aged less than two years old].</title><author><name sortKey="Calvo Rey, C" sort="Calvo Rey, C" uniqKey="Calvo Rey C" first="C" last="Calvo Rey">C. Calvo Rey</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain. ccalvo@mi.madritel.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García García">M L García García</name></author><author><name sortKey="Casas Flecha, I" sort="Casas Flecha, I" uniqKey="Casas Flecha I" first="I" last="Casas Flecha">I. Casas Flecha</name></author><author><name sortKey="Martin Del Valle, F" sort="Martin Del Valle, F" uniqKey="Martin Del Valle F" first="F" last="Martín Del Valle">F. Martín Del Valle</name></author><author><name sortKey="Centeno Jimenez, M" sort="Centeno Jimenez, M" uniqKey="Centeno Jimenez M" first="M" last="Centeno Jiménez">M. Centeno Jiménez</name></author><author><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez-Bre A">P. Pérez-Bre A</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15989867</idno><idno type="pmid">15989867</idno><idno type="doi">10.1157/13076763</idno><idno type="wicri:Area/Main/Corpus">00619</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00619</idno><idno type="wicri:Area/Main/Curation">000619</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000619</idno><idno type="wicri:Area/Main/Exploration">000619</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Influenza virus infections in infants aged less than two years old].</title><author><name sortKey="Calvo Rey, C" sort="Calvo Rey, C" uniqKey="Calvo Rey C" first="C" last="Calvo Rey">C. Calvo Rey</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain. ccalvo@mi.madritel.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García García">M L García García</name></author><author><name sortKey="Casas Flecha, I" sort="Casas Flecha, I" uniqKey="Casas Flecha I" first="I" last="Casas Flecha">I. Casas Flecha</name></author><author><name sortKey="Martin Del Valle, F" sort="Martin Del Valle, F" uniqKey="Martin Del Valle F" first="F" last="Martín Del Valle">F. Martín Del Valle</name></author><author><name sortKey="Centeno Jimenez, M" sort="Centeno Jimenez, M" uniqKey="Centeno Jimenez M" first="M" last="Centeno Jiménez">M. Centeno Jiménez</name></author><author><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez-Bre A">P. Pérez-Bre A</name></author></analytic><series><title level="j">Anales de pediatria (Barcelona, Spain : 2003)</title><idno type="ISSN">1695-4033</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (physiopathology)</term><term>Male (MeSH)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (physiopathologie)</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term><term>Infections de l'appareil respiratoire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Influenza is a major cause of respiratory tract illness in infants. The clinical characteristics of these infections are non-specific and the burden of influenza is frequently underestimated in very young children. The objective of this study was to describe confirmed influenza infections in infants < 2 years attended in a level II public hospital. A second-rate aim was to compare influenza infections in hospitalized infants with respiratory syncytial virus (VRS) infection in the same population.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS AND METHODS</b></p><p>We performed a descriptive, prospective study between 1991 and 2003 in infants younger than 24 months of age, who were admitted to the Severo Ochoa Hospital (Leganés. Madrid) with fever or respiratory tract infection. Virological diagnosis was made with direct immunofluorescent assay and/or reverse transcription-polymerase chain reaction on specimens obtained from nasopharyngeal washings. The patients' clinical characteristics were recorded. Patients with influenza infection were compared with a similar group of infants with RSV infection.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We analyzed hospitalized 100 infants with influenza infection. Influenza caused 4.1% of the admissions in infants with fever or respiratory tract infection. Influenza A was isolated in 83%, influenza B in 12% and influenza C in 5% of the patients. The mean age of hospitalized infants was 8.3 +/- 5.9 months and the most frequent clinical diagnoses were bronchiolitis in 38%, recurrent wheezing in 25%, upper respiratory tract infection in 19% and pneumonia in 9%. Fever > 38 degrees C was present in 83% of the patients. Radiologic infiltrate was found in 65% of the children. Oxygen saturation less then 95% was present in 44%. In children under 6 months of age fever was less frequent (p = 0.049) and upper respiratory tract infection was more frequent (p = 0.01). Patients with influenza virus infection were older (p = 0.002), more frequently presented fever (p < 0.0001) and radiologic infiltrate (p < 0.001) than infants with RSV infection. Bronchiolitis was more frequent in the RSV group (p = 0.006).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Influenza infection is a major cause of respiratory tract disease in hospitalized infants. It is an etiologic cause of bronchiolitis, recurrent wheezing, and fever and radiologic consolidations are frequent. Clinical presentation is milder in children under 6 month of age. The characteristics of influenza infection differ substantially from those of RSV infection.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15989867</PMID><DateCompleted><Year>2005</Year><Month>09</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1695-4033</ISSN><JournalIssue CitedMedium="Print"><Volume>63</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Anales de pediatria (Barcelona, Spain : 2003)</Title><ISOAbbreviation>An Pediatr (Barc)</ISOAbbreviation></Journal><ArticleTitle>[Influenza virus infections in infants aged less than two years old].</ArticleTitle><Pagination><MedlinePgn>22-8</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Influenza is a major cause of respiratory tract illness in infants. The clinical characteristics of these infections are non-specific and the burden of influenza is frequently underestimated in very young children. The objective of this study was to describe confirmed influenza infections in infants < 2 years attended in a level II public hospital. A second-rate aim was to compare influenza infections in hospitalized infants with respiratory syncytial virus (VRS) infection in the same population.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">We performed a descriptive, prospective study between 1991 and 2003 in infants younger than 24 months of age, who were admitted to the Severo Ochoa Hospital (Leganés. Madrid) with fever or respiratory tract infection. Virological diagnosis was made with direct immunofluorescent assay and/or reverse transcription-polymerase chain reaction on specimens obtained from nasopharyngeal washings. The patients' clinical characteristics were recorded. Patients with influenza infection were compared with a similar group of infants with RSV infection.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We analyzed hospitalized 100 infants with influenza infection. Influenza caused 4.1% of the admissions in infants with fever or respiratory tract infection. Influenza A was isolated in 83%, influenza B in 12% and influenza C in 5% of the patients. The mean age of hospitalized infants was 8.3 +/- 5.9 months and the most frequent clinical diagnoses were bronchiolitis in 38%, recurrent wheezing in 25%, upper respiratory tract infection in 19% and pneumonia in 9%. Fever > 38 degrees C was present in 83% of the patients. Radiologic infiltrate was found in 65% of the children. Oxygen saturation less then 95% was present in 44%. In children under 6 months of age fever was less frequent (p = 0.049) and upper respiratory tract infection was more frequent (p = 0.01). Patients with influenza virus infection were older (p = 0.002), more frequently presented fever (p < 0.0001) and radiologic infiltrate (p < 0.001) than infants with RSV infection. Bronchiolitis was more frequent in the RSV group (p = 0.006).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Influenza infection is a major cause of respiratory tract disease in hospitalized infants. It is an etiologic cause of bronchiolitis, recurrent wheezing, and fever and radiologic consolidations are frequent. Clinical presentation is milder in children under 6 month of age. The characteristics of influenza infection differ substantially from those of RSV infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calvo Rey</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain. ccalvo@mi.madritel.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García García</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Casas Flecha</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Martín del Valle</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Centeno Jiménez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Breña</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>spa</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Infecciones por virus de la gripe en menores de dos años.</VernacularTitle></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>An Pediatr (Barc)</MedlineTA><NlmUniqueID>101162596</NlmUniqueID><ISSNLinking>1695-4033</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>7</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>9</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>7</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15989867</ArticleId><ArticleId IdType="pii">13076763</ArticleId><ArticleId IdType="doi">10.1157/13076763</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Casas Flecha, I" sort="Casas Flecha, I" uniqKey="Casas Flecha I" first="I" last="Casas Flecha">I. Casas Flecha</name><name sortKey="Centeno Jimenez, M" sort="Centeno Jimenez, M" uniqKey="Centeno Jimenez M" first="M" last="Centeno Jiménez">M. Centeno Jiménez</name><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García García">M L García García</name><name sortKey="Martin Del Valle, F" sort="Martin Del Valle, F" uniqKey="Martin Del Valle F" first="F" last="Martín Del Valle">F. Martín Del Valle</name><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez-Bre A">P. Pérez-Bre A</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Calvo Rey, C" sort="Calvo Rey, C" uniqKey="Calvo Rey C" first="C" last="Calvo Rey">C. Calvo Rey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000612 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000612 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeEspagneV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:15989867
|texte= [Influenza virus infections in infants aged less than two years old].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:15989867" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeEspagneV1
| This area was generated with Dilib version V0.6.37. |  |